Functional Suppression by FoxP3+CD4+CD25highRegulatory T Cells during Acute Hepatitis C Virus Infection
The Journal of Infectious Diseases2007Vol. 197(1), pp. 46–57
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Susan Smyk‐Pearson, Lucy Golden‐Mason, Jared Klarquist, James R. Burton, Ian A. Tester, Chia C. Wang, Nicole Culbertson, Arthur A. Vandenbark, Hugo R. Rosen
Abstract
Collectively, these data indicate that patients with acute HCV infection who develop chronicity versus spontaneous resolution exhibit temporal changes in T(reg) cell function. It is possible that repetitive viral antigenic stimulation alters the function of T(reg) cells over time.
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