A Deletion in the Chemokine Receptor 5 (CCR5) Gene Is Associated with Tickborne Encephalitis
The Journal of Infectious Diseases2008Vol. 197(2), pp. 266–269
Citations Over TimeTop 1% of 2008 papers
Elin Kindberg, Auksė Mickienė, Cecilia Ax, Britt Åkerlind, Sirkka Vene, Lars Lindquist, Åke Lundkvist, Lennart Svensson
Abstract
Tickborne encephalitis (TBE) virus infections can be asymptomatic or cause moderate to severe injuries of the central nervous system. Why some individuals develop severe disease is unknown, but a role for host genetic factors has been suggested. To investigate whether chemokine receptor CCR5 is associated with TBE, CCR5Delta32 genotyping was performed among Lithuanian patients with TBE (n=129) or with aseptic meningoencephalitis (n=76) as well as among control subjects (n=134). We found individuals homozygous for CCR5Delta32 (P= .026) only among patients with TBE and a higher allele prevalence among patients with TBE compared with the other groups studied. CCR5Delta32 allele prevalence also increased with the clinical severity of disease.
Related Papers
- → Cerebrospinal fluid CXCL13 is a prognostic marker for aseptic meningitis(2014)17 cited
- → Evidence of Toscana virus circulation in Umbria: First report(2003)36 cited
- RATE OF LEPTOSPIRAL MENINGITIS AND MENINGOENCEPHALITIS IN TEHRAN(2009)
- [Case report of aseptic meningitis due to Japanese encephalitis virus].(2007)
- Rate of leptospiral meningitis and(2009)