Dynamics of Total, Linear Nonintegrated, and Integrated HIV‐1 DNA In Vivo and In Vitro
The Journal of Infectious Diseases2008Vol. 197(3), pp. 411–419
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Kersten K. Koelsch, Lin Liu, Richard Haubrich, Susanne May, Diane V. Havlir, Huldrych F. Günthard, Caroline Ignacio, Paula Campos‐Soto, Susan J. Little, Robert W. Shafer, Gregory K. Robbins, Richard T. D’Aquila, Yuji Kawano, K K Young, Phillip Dao, Celsa A. Spina, Douglas D. Richman, Joseph K. Wong
Abstract
Total HIV-1 DNA decays rapidly with suppression of virus replication in vivo. Clearance of HIV-1 DNA during the first 6 months of therapy reflects a disproportionate loss of nonintegrated HIV-1 DNA genomes, suggesting that levels of total HIV-1 DNA in PBMCs after prolonged virus suppression largely represent integrated HIV-1 genomes.
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