Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy
The Journal of Infectious Diseases2008Vol. 197(4), pp. 563–571
Citations Over TimeTop 1% of 2008 papers
Florencia Pereyra, Marylyn M. Addo, Daniel E. Kaufmann, Yang Liu, Toshiyuki Miura, Almas Rathod, B.M. Baker, Alicja Trocha, Rachel Rosenberg, Elizabeth W. Mackey, Peggy Ueda, Zhigang Lu, Dani Cohen, Terri Wrin, Christos J. Petropoulos, Eric Rosenberg, Bruce D. Walker
Abstract
Elite controllers are a distinct group, even when compared to persons with low level viremia, but they exhibit marked genetic and immunologic heterogeneity. Even low-level viremia among HIV controllers was associated with measurable T cell dysfunction, which has implications for current prophylactic vaccine strategies.
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