Impact of Meningococcal Serogroup C Conjugate Vaccines on Carriage and Herd Immunity
The Journal of Infectious Diseases2008Vol. 197(5), pp. 737–743
Citations Over TimeTop 1% of 2008 papers
Martin Maiden, Ana Belén Ibarz-Pavón, Rachel Urwin, Stephen J. Gray, Nicholas Andrews, Stuart C. Clarke, A M Walker, M.R. Evans, J. Simon Kroll, Keith Neal, Dlawer A. A. Ala’Aldeen, Derrick W. Crook, Kathryn Cann, Sarah Harrison, Richard Cunningham, David Baxter, Edward B. Kaczmarski, Jenny MacLennan, J. Claire Cameron, James M. Stuart
Abstract
The impact of vaccination with MCC vaccine on the prevalence of carriage of group C meningococci was consistent with herd immunity. The high impact on the carriage of ST-11 complex serogroup C could be attributed to high levels of capsule expression. High vaccine efficacy against disease in young children, who were not protected long-term by the schedule initially used, is attributed to the high vaccine efficacy against carriage in older age groups.
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