Varicella‐Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine
The Journal of Infectious Diseases2008Vol. 197(6), pp. 825–835
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Myron J. Levin, Michael N. Oxman, J. H. Zhang, Gary R. Johnson, H. STANLEY, Anthony Hayward, Michael J. Caulfield, Michael R. Irwin, Jeffrey G. Smith, J. Clair, I. S. F. Chan, Heather Williams, Ruth Harbecke, Rocio D. Marchese, Stephen E. Straus, Anne A. Gershon, Adriana Weinberg, Veterans Affairs Cooperative Studies Program Shingles Prevention Study Investigators
Abstract
The zoster vaccine induced a significant increase in VZV-CMI and VZV antibody. The magnitude and duration of the boost in VZV-CMI in vaccine recipients and the relationship of this boost to age paralleled the clinical effects of the vaccine observed during the efficacy trial. These findings support the hypothesis that boosting VZV-CMI protects older adults against herpes zoster and postherpetic neuralgia.
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