Comparison of Pneumococcal Conjugate Polysaccharide and Free Polysaccharide Vaccines in Elderly Adults: Conjugate Vaccine Elicits Improved Antibacterial Immune Responses and Immunological Memory
Clinical Infectious Diseases2008Vol. 46(7), pp. 1015–1023
Citations Over TimeTop 1% of 2008 papers
A de Roux, Beate Schmöele-Thoma, George R. Siber, Jill Hackell, A. Kuhnke, N. Ahlers, Shirley Baker, Ahmad Razmpour, Emilio A. Emini, Philip Fernsten, William C. Gruber, Stephen Lockhart, Olaf Burkhardt, Tobias Welte, H. Lode
Abstract
In adults, an initial dose of 7vPnC is likely to elicit higher and potentially more effective levels of antipneumococcal antibodies than is PPV. In contrast with PPV, for which the induction of hyporesponsiveness was observed when used as a priming dose, 7vPnC elicits an immunological state that permits subsequent administration of 7vPnC or PPV to maintain functional antipolysaccharide antibody levels.
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