Severe Renal Dysfunction and Risk Factors Associated with Renal Impairment in HIV‐Infected Adults in Africa Initiating Antiretroviral Therapy
Clinical Infectious Diseases2008Vol. 46(8), pp. 1271–1281
Citations Over TimeTop 10% of 2008 papers
Andrew Reid, Wolfgang Stöhr, A Sarah Walker, Ian Williams, Cissy Kityo, Peter J. Hughes, Andrew Kambugu, Charles F. Gilks, Peter Mugyenyi, Paula Munderi, James Hakim, Diana M. Gibb, Development of Antiretroviral Therapy Trial
Abstract
Despite screening, mild-to-moderate baseline renal impairment was relatively common, but these participants had greatest increases in eGFR after starting ART. Severe eGFR impairment was infrequent regardless of ART regimen and was generally related to intercurrent disease. Differences between ART regimens with respect to changes in eGFR through 96 weeks were of marginal clinical relevance, but investigating longer-term nephrotoxicity remains important.
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