Host Polymorphisms in Interleukin 4, Complement Factor H, and C‐Reactive Protein Associated with Nasal Carriage ofStaphylococcus aureusand Occurrence of Boils
The Journal of Infectious Diseases2008Vol. 197(9), pp. 1244–1253
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Marieke Emonts, André G. Uitterlinden, Jan Nouwen, Isabella Kardys, Moniek P.M. de Maat, Damian C. Melles∗, Jacqueline C.M. Witteman, Paulus T. V. M. de Jong, Henri A. Verbrugh, Albert Hofman, Peter W. M. Hermans, Alex van Belkum
Abstract
Persistent carriage of S. aureus is influenced by genetic variation in host inflammatory response genes. As would be expected in multifactorial host-microbe interactions, these effects are limited. Interestingly, host genotype was associated with the carriage of certain S. aureus genotypes. Apparently, a close interaction between host and bacterial determinants are prerequisites for long-term colonization.
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