Comparison of Virulence in Community‐Associated Methicillin‐ResistantStaphylococcus aureusPulsotypes USA300 and USA400 in a Rat Model of Pneumonia
The Journal of Infectious Diseases2008Vol. 198(4), pp. 561–570
Citations Over TimeTop 10% of 2008 papers
Christopher P. Montgomery, Susan Boyle‐Vavra, Patricia Adem, Jean C. Lee, Aliya N. Husain, Julia Clasen, Robert S. Daum
Abstract
USA300 isolates were more virulent than USA400 isolates in a model of necrotizing pneumonia. The explanation for this is unclear, but it likely results from increased expression of S. aureus regulatory systems (e.g., agr, saeRS, and sarA) and the resultant upregulation of key virulence factors including alpha-toxin and PVL.
Related Papers
- → Community‐Acquired Methicillin‐ResistantStaphylococcus aureusInfections in France: Emergence of a Single Clone That Produces Panton‐Valentine Leukocidin(2002)513 cited
- [Staphylococcus aureus septicemia producing Panton-Valentine leukocidin. 3 cases].(1997)
- → More than just a simple abscess: could it be caused by Panton–Valentine leukocidin positive Staphylococcus aureus?(2011)1 cited
- → Infección grave por Staphylococcus aureus meticilino sensible productor de leucocidina de Panton-Valentine: reportes de dos casos(2016)1 cited
- Research on the Panton-Valentine Leukocidin Gene of Methicillin-resistant Staphylococcus Aureus(2010)