Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut
Clinical Infectious Diseases2009Vol. 49(2), pp. 262–270
Citations Over TimeTop 10% of 2009 papers
Michel J. van Vliet, Wim J. E. Tissing, Catharina A. J. Dun, Nico E. L. Meessen, Willem A. Kamps, Eveline S.J.M. de Bont, Hermie J. M. Harmsen
Abstract
Patients with acute myeloid leukemia treated with chemotherapy and prophylactic antibiotics are unable to maintain colonization resistance because of a decrease in anaerobic bacteria and an increase in potentially pathogenic aerobic enterococci. We hypothesize that this disturbance in the balance between anaerobic and aerobic bacteria will further increase the risk of gram-positive aerobic infections among immunocompromised patients with cancer.
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