Dynamics of Adaptive Microevolution of HypermutablePseudomonas aeruginosaduring Chronic Pulmonary Infection in Patients with Cystic Fibrosis
The Journal of Infectious Diseases2009Vol. 200(1), pp. 118–130
Citations Over TimeTop 10% of 2009 papers
Christina Hoboth, Reinhard Hoffmann, Anja Eichner, Christine Henke, Sabine Schmoldt, Axel Imhof, Jürgen Heesemann, Michael Hogardt
Abstract
These changes indicate an adaptive shift toward constitutive expression of genes required for growth under the nutritional and microaerobic conditions created by suppurative secretions in the lungs of patients with CF. In addition, these results provide important clues about the persistence strategies used by P. aeruginosa during progressive CF lung disease.
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