Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV‐Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients
Clinical Infectious Diseases2009Vol. 49(5), pp. 702–709
Citations Over TimeTop 10% of 2009 papers
Tihana Bicanic, Conrad Muzoora, Annemarie E. Brouwer, Graeme Meintjes, Nicky Longley, Kabanda Taseera, Kevin Rebe, Angela Loyse, Joseph N Jarvis, Linda‐Gail Bekker, Robin Wood, Direk Limmathurotsakul, Wirongrong Chierakul, Kasia Stepniewska, Nicholas J. White, Shabbar Jaffar, Thomas S. Harrison
Abstract
The results support the use of the rate of clearance of infection or early fungicidal activity as a means to explore antifungal drug dosages and combinations in phase II studies. An increased understanding of how the factors determining outcome interrelate may help clarify opportunities for intervention.
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