Impact of Hepatitis B Virus Infection on Human Immunodeficiency Virus Response to Antiretroviral Therapy in Nigeria
Clinical Infectious Diseases2009Vol. 49(8), pp. 1268–1273
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John Idoko, Seema Meloni, Mohammed Muazu, Ladep Nimzing, Bitrus Badung, Claudia Hawkins, Jean‐Louis Sankalé, Ernest Ekong, Robert L. Murphy, Phyllis J. Kanki, Chloe L. Thio
Abstract
Among HIV-infected Nigerian individuals, HBV coinfection, especially among those with high levels of HBV replication, was associated with lower CD4+ T cell counts at ART initiation, independent of HIV RNA level. Patients with HBeAg-positive status had a slower virological response to ART, compared with HBeAg-negative patients. Further work is needed to understand the effects of HBV on CD4+ T cells.
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