Association between Severe Pandemic 2009 Influenza A (H1N1) Virus Infection and Immunoglobulin G2 Subclass Deficiency
Clinical Infectious Diseases2010Vol. 50(5), pp. 672–678
Citations Over TimeTop 10% of 2010 papers
Claire L. Gordon, Paul D. R. Johnson, Michael Permezel, Natasha E. Holmes, G. A. Gutteridge, Christine F. McDonald, Damon P. Eisen, Andrew J. Stewardson, John Edington, P. G. P. Charles, Nick Crinis, M. Jane Black, Joseph Torresi, M. Lindsay Grayson
Abstract
Severe H1N1 infection is associated with IgG(2) deficiency, which appears to persist in a majority of patients. Pregnancy-related reductions in IgG(2) level may explain the increased severity of H1N1 infection in some but not all pregnant patients. The role of IgG(2) deficiency in the pathogenesis of H1N1 infection requires further investigation, because it may have therapeutic implications.
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