Influence of Age and Nature of Primary Infection on Varicella‐Zoster Virus–Specific Cell‐Mediated Immune Responses
The Journal of Infectious Diseases2010Vol. 201(7), pp. 1024–1030
Citations Over TimeTop 10% of 2010 papers
Adriana Weinberg, Ann Lazar, Gary O. Zerbe, Anthony Hayward, Ivan S. F. Chan, Rupert Vessey, Jeffrey L. Silber, Rob Roy MacGregor, Kenny Chan, Anne A. Gershon, Myron J. Levin
Abstract
In immunocompetent individuals with prior varicella, VZV RCF peaked in early adulthood. Administration of varicella vaccine to HIV-infected or uninfected individuals aged >5 years generated VZV RCF values similar to those of immunocompetent individuals with immunity induced by wild-type infection. A zoster vaccine increased the VZV RCF of elderly adults aged <75 years to values higher than peak values induced by wild-type infection.
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