Epstein‐Barr Virus–Associated Hemophagocytic Lymphohistiocytosis in Adults Characterized by High Viral Genome Load within Circulating Natural Killer Cells
Clinical Infectious Diseases2010Vol. 51(1), pp. 66–69
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Christopher P. Fox, C. Shannon‐Lowe, Philip Gothard, Bhuvan Kishore, Jeffrey R. Neilson, Nathan O’Connor, Martin Rowe
Abstract
Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.
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