Paucity of Initial Cerebrospinal Fluid Inflammation in Cryptococcal Meningitis Is Associated with Subsequent Immune Reconstitution Inflammatory Syndrome
The Journal of Infectious Diseases2010Vol. 202(6), pp. 962–970
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David R. Boulware, Shulamith Bonham, David B. Meya, Darin L. Wiesner, Gregory S. Park, Andrew Kambugu, Edward N. Janoff, Paul R. Bohjanen
Abstract
Patients who subsequently develop CM-related IRIS exhibit less initial CSF inflammation at the time of CM diagnosis, compared with those who do not develop IRIS. The inflammatory CSF cytokine profiles observed at time of IRIS can distinguish IRIS from CM relapse.
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