Mediators of Innate and Adaptive Immune Responses Differentially Affect Immune Restoration Disease Associated withMycobacterium tuberculosisin HIV Patients Beginning Antiretroviral Therapy
The Journal of Infectious Diseases2010Vol. 202(11), pp. 1728–1737
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Benjamin G. Oliver, Julian Elliott, Patricia Price, Michael Phillips, Vonthanak Saphonn, Mean Chhi Vun, John Kaldor, David A. Cooper, Martyn A. French
Abstract
Perturbations of the innate immune response to M. tuberculosis before and during ART may contribute to the immunopathology of TB-IRIS, whereas elevated IL-18 alone suggests adaptive immune responses predominate in ART-TB. These findings may have implications for therapy in TB-IRIS.
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