Long‐Term Survival of HIV‐Infected Children Receiving Antiretroviral Therapy in Thailand: A 5‐Year Observational Cohort Study
Clinical Infectious Diseases2010Vol. 51(12), pp. 1449–1457
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Intira Jeannie Collins, Gonzague Jourdain, Rawiwan Hansudewechakul, Suparat Kanjanavanit, Suchat Hongsiriwon, Chaiwat Ngampiyasakul, Somboon Sriminiphant, Pornchai Technakunakorn, Nicole Ngo‐Giang‐Huong, Trinh Duong, Sophie Le Cœur, Shabbar Jaffar, Marc Lallemant
Abstract
Children who initiated ART as infants after meeting immunological and/or clinical criteria had a high risk of mortality which persisted beyond the first year of therapy. Among older children, those with severe wasting or low CD4 cell percentage at treatment initiation were at high risk of mortality during the first 6 months of therapy. These findings support the scale-up of early HIV diagnosis and immediate treatment in infants, before advanced disease progression in older children.