Impact of CYP2D6 Polymorphism on Steady-State Plasma Levels of Risperidone and 9-Hydroxyrisperidone in Thai Children and Adolescents with Autism Spectrum Disorder
Journal of Child and Adolescent Psychopharmacology2016Vol. 27(2), pp. 185–191
Citations Over TimeTop 10% of 2016 papers
Natchaya Vanwong, Nattawat Ngamsamut, Sadeep Medhasi, Apichaya Puangpetch, Monpat Chamnanphon, Teerarat Tan-kam, Yaowaluck Hongkaew, Penkhae Limsila, Chonlaphat Sukasem
Abstract
This is the first study to investigate the effects of CYP2D6 genetic polymorphisms on the plasma concentrations of risperidone in Thai children with ASD. The findings indicate that CYP2D6 polymorphisms affect the plasma concentrations of risperidone and the risperidone/9-hydroxyrisperidone ratio. Genetic screening for CYP2D6 polymorphisms could help to predict unexpected adverse events caused by the higher plasma concentration of risperidone.
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