Functions of Thyroid Hormone Receptors in Mice
Citations Over TimeTop 1% of 2000 papers
Abstract
Thyroid hormone receptors (TRs) play a central role in mediating the actions of thyroid hormone in development and homeostasis in vertebrate species. The TRs are nuclear receptors that act as ligand-regulated transcription factors. There are two TR genes (TRalpha and TRbeta), each capable of generating different variant products, suggesting a potentially complex array of TR pathways. Targeted mutagenesis in the mouse has indicated that there are specific individual functions for the TR genes in vivo. The deletion of combinations of TRalpha and TRbeta variants has revealed that additional functions are convergently regulated by both TR genes and indicates that control of an extended range of functions is facilitated by a network of specific and common TR pathways. The TR-deficient mouse models have allowed investigation of the TR pathways underlying many functions of thyroid hormone and provide a unique perspective on receptor-mediated mechanisms of biological control.
Related Papers
- → Main Factors Involved in Thyroid Hormone Action(2021)23 cited
- → Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor(1995)165 cited
- → Thyroid System-Disrupting Chemicals: Interference with Thyroid Hormone Binding to Plasma Proteins and the Cellular Thyroid Hormone Signaling Pathway(2006)14 cited
- → Thyroid Hormone Receptors(2004)4 cited
- Nuclear localization of protein kinase C- induces thyroid hormone receptor-1 expression in the cardiomyocyte(2006)