Selenium Supplementation in the Treatment of Hashimoto's Thyroiditis: A Systematic Review and a Meta-analysis
Thyroid2010Vol. 20(10), pp. 1163–1173
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Konstantinos A. Toulis, Athanasios D. Anastasilakis, Thrasyvoulos Tzellos, Dimitrios G. Goulis, Dimitrios Kouvelas
Abstract
On the basis of the best available evidence, Se supplementation is associated with a significant decrease in TPOab titers at 3 months and with improvement in mood and/or general well-being. Evidence suggests a different pattern of response to Se supplementation in HT relative to baseline TPOab titers, and this, if confirmed, could be used to identify which patients would benefit most from treatment. An improvement in thyroid function and morphology should be demonstrated before Se routine supplementation can be recommended in the treatment of HT.
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