Clinical and pathologic features of ‘sporadic’ papillary thyroid carcinoma registered in 2005-2008 years in children and adolescents of Belarus

Citations Over TimeTop 10% of 2012 papers

Abstract

Abstract Background: A systematic analysis of clinical and pathologic patterns of childhood 'sporadic' thyroid carcinoma in Belarus in the absence of the Chernobyl radioiodine has never been performed before. The aim of this study was to establish the main 'sporadic' PTC essentials in Belarusian children and adolescents, and relationship of tumor pathology with extrathyroid extension and lymph node metastases. Methods: This was a retrospective population-based study with assessment of histological samples of 119 cases of thyroid cancer in Belarusian children and adolescents of 0-18 years old registered during 2005-2008 years. Sporadic papillary thyroid carcinoma was established in 94 unexposed children, none had a follicular thyroid cancer. Results: The incidence rate of PTC was 1.13 per 100 000, median age at diagnosis was 15.1 years with 4-fold predominance of females. Relapse was detected in 2% of cases with median follow-up 4.2 years. Median tumor size was 12 mm, total number of PTC cases with multifocal growth was 3%. Classical variant of PTC was registered in 46%, follicular in 20%, tall cell in 12% of cases. Percentages of rare types of PTC (tall cell and diffuse sclerosing) were equal to solid PTC (13%, 12% and 10%, respectively). Adolescents had a pure papillary carcinoma more often comparing to children who represented tumors with mixed papillary/follicular patterns more frequently (p<0.05). Two of third PTC cases had regional lymph nodes metastases. Extrathyroid extension (ETE) was established in 39 of 74 patients in whom ETE could be assessed by morphology. Multivariate analysis showed that lymphatic invasion was the strongest independent factor associated with both extrathyroid extension (p<0.0001) and lymph nodes metastases (p<0.0001). Conclusion: In 2005-2008, sporadic thyroid cancer in children of Belarus was represented by high prevalence of PTC and absence of follicular thyroid cancer. Sporadic PTC in Belarus displayed lower tumor size, small number of cases with multifocal growth, equal number of rare types and solid PTC, prevalence of pure papillary variant in adolescents, and a low frequency of early relapses. High frequency of ETE and lymph nodes metastases was detected, and the strongest morphology factor associated with both of them was lymphatic invasion.

Related Papers

• → Biological behavior and prognosis of familial papillary thyroid carcinoma(2008)106 cited
• → Morphological and Histological Study on Thyroid Gland Toxicity in Male Rats Exposed to Mercury(2020)1 cited
• → The Experimental Development and Metabolism of Thyroid Gland Tumors(1955)36 cited
• I(131)使用による白鼠甲状腺機能に関する実験的研究 第1編 抗甲状腺剤，甲状腺剤，甲状腺刺戟ホルモンの白鼠甲状腺に及ぼす影響(1959)
• Susquehanna Chorale Spring Concert "Roots and Wings"(2017)