Reflex BRAF Testing in Thyroid Fine-Needle Aspiration Biopsy with Equivocal and Positive Interpretation: A Prospective Study
Thyroid2011Vol. 21(7), pp. 717–723
Citations Over TimeTop 10% of 2011 papers
Adebowale Adeniran, Constantine Theoharis, Pei Hui, Manju L. Prasad, Lynwood Hammers, Tobias Carling, Robert Udelsman, David C. Chhieng
Abstract
BRAF V600E mutation analysis can be easily performed on cytologic preparation using lavage fluids obtained from needle rinsing. By combining morphologic evaluation and BRAF testing, there is a substantial improvement in the preoperative identification of PTC when compared with cytology alone. Patients with equivocal cytologic diagnosis and BRAF V600E mutation are candidates for total thyroidectomy ± central lymph node dissection.
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