Papillary Thyroid Carcinomas with Cervical Lymph Node Metastases Can Be Stratified into Clinically Relevant Prognostic Categories Using Oncogenic BRAF , the Number of Nodal Metastases, and Extra-Nodal Extension
Thyroid2012Vol. 22(6), pp. 575–584
Citations Over TimeTop 10% of 2012 papers
Julio C. Ricarte‐Filho, Ian Ganly, Michael Rivera, Nora Katabi, Weimin Fu, Ashok R. Shaha, R. Michael Tuttle, James A. Fagin, Ronald Ghossein
Abstract
(i) The number of metastatic LN is an independent predictor of recurrence in all age groups and identifies a subset of young patients with excellent prognosis who may not benefit from RAI therapy. (ii) Combined positivity for BRAF and extra-nodal extension has additive prognostic value in predicting DSS. (iii) Classification systems that assign the same magnitude of risk for recurrence or death to all patients with N1 disease should be revisited.
Related Papers
- → Nodal signaling induces the midline barrier by activatingNodalexpression in the lateral plate(2003)108 cited
- → Wave pinning and spatial patterning in a mathematical model of Antivin/Lefty–Nodal signalling(2012)10 cited
- → Long-range action of Nodal requires interaction with GDF1(2007)115 cited
- → Complexity of AV Nodal Function: Complex Nodal Structure or Complex Behavior of Nodal Elements?(1988)10 cited
- [Regulation of nodal excesses in young chick blastoderms. I. Implantation of a second Hensen's node into the post-nodal area of the primitive streak].(1974)