Modulation of Sodium/Iodide Symporter Expression in the Salivary Gland
Thyroid2013Vol. 23(8), pp. 1029–1036
Citations Over TimeTop 10% of 2013 papers
Krista M. D. La Perle, Dong Chul Kim, Nathan C. Hall, Adam J. Bobbey, Daniel H. Y. Shen, Rebecca Nagy, Paul E. Wakely, Amy Lehman, David Jarjoura, Sissy Jhiang
Abstract
NIS expression is tightly modulated during the transition of intercalated to striated ducts and striated to excretory ducts in salivary ductal cells. NIS expression in salivary glands is decreased during inflammation and tumor formation. Further investigation may identify molecular targets and/or pharmacologic agents that allow selective inhibition of NIS expression/activity in salivary glands during radioactive iodine treatment.
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