Impact of Metformin and Compound C on NIS Expression and Iodine Uptake In Vitro and In Vivo: A Role for CRE in AMPK Modulation of Thyroid Function
Thyroid2013Vol. 24(1), pp. 78–87
Citations Over TimeTop 23% of 2013 papers
Randa M. Abdulrahman, Mariëtte R. Boon, Hetty C. M. Sips, Bruno Guigas, Patrick C.N. Rensen, Johannes W. A. Smit, Guido C. Hovens
Abstract
NIS expression and iodine uptake in thyrocytes can be modulated by metformin and compound C. These compounds exert their effect by modulation of AMPK, which, in turn, regulates the activation of the CRE element in the NIS promoter. Overall, this suggests that the use of AMPK modulating compounds may be useful for the enhancement of iodide uptake by thyrocytes, which could be useful for the treatment of thyroid cancer patients with radioactive iodine.
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