An International Multi-Institutional Validation of Age 55 Years as a Cutoff for Risk Stratification in the AJCC/UICC Staging System for Well-Differentiated Thyroid Cancer
Thyroid2016Vol. 26(3), pp. 373–380
Citations Over TimeTop 1% of 2016 papers
Iain J. Nixon, Laura Y. Wang, Jocelyn Migliacci, Antoine Eskander, Michael J. Campbell, Ahmad Aniss, Lilah F. Morris, Fernanda Vaisman, Rossana Corbo, Denise Momesso, Mário Vaisman, André Lopes Carvalho, Diana Learoyd, William D. Leslie, Richard W. Nason, Deborah Kuk, Volkert B. Wreesmann, Luc G.T. Morris, Frank L. Palmer, Ian Ganly, Snehal G. Patel, Bhuvanesh Singh, R. Michael Tuttle, Ashok R. Shaha, Mithat Gönen, Kumar Alok Pathak, Wen T. Shen, Mark Sywak, Luiz Paulo Kowalski, Jeremy L. Freeman, Nancy D. Perrier, Jatin P. Shah
Abstract
A change in the cutoff age in the current AJCC/UICC staging system from 45 years to 55 years would lead to a downstaging of 12% of patients, and would improve the statistical validity of the model. Such a change would be clinically relevant for thousands of patients worldwide by preventing overstaging of patients with low-risk disease while providing a more realistic estimate of prognosis for those who remain high risk.
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