Role of the Innate Cytokine Storm Induced by the Influenza A Virus
Citations Over TimeTop 10% of 2019 papers
Abstract
Influenza A viruses (IAVs) can be classified into dozens of subtypes based on their hemagglutinin (HA) and neuraminidase (NA) proteins. To date, 18 HA subtypes and 11 NA subtypes of IAVs that spread in animals and humans have been found. Following infection, the IAV first induces the innate immune system, which can rapidly recruit innate immune cells and cytokines to the site of infection. Influenza-induced cytokine storms have been associated with uncontrolled proinflammatory responses, which may lead to significant immunopathy and severe disease. Cytokine storms are complicated by several types of cytokines and chemokines that have various activities. In addition to their direct effects, their crossregulation causes cytokine networks to form; these networks determine the outcome of viral infections. In this review, we focus on cytokine storms and their signaling pathways that are triggered by the different subtypes of IAV.
Related Papers
- ESTABLISHMENT AND APPLICATION OF HIGH THROUGHPUT SCREENING MODEL FOR INFLUENZA VIRUS NEURAMINIDASE INHIBITORS IN VITRO(2002)
- → Paper-Based Neuraminidase Assay Sensor for Detection of Influenza Viruses(2016)1 cited
- → Production of Neuraminidase in Cell Monolayers infected with Influenza Virus(1970)9 cited
- → Neuraminidase Inhibitors as Anti‐Influenza Agents(2011)1 cited
- Determination of anti-influenza virus neuraminidase activity of L20051117 and AMMS607(2009)