FoldIndex(C): a simple tool to predict whether a given protein sequence is intrinsically unfolded
Computer applications in the biosciences2005Vol. 21(16), pp. 3435–3438
Citations Over TimeTop 1% of 2005 papers
Jaime Prilusky, Clifford E. Felder, Tzviya Zeev‐Ben‐Mordehai, Edwin H. Rydberg, Orna Man, J. Beckmann, Israel Silman, Joel L. Sussman
Abstract
An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.
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