CEREBRAL BLOOD FLOW, BLOOD VOLUME AND OXYGEN UTILIZATION
Citations Over TimeTop 10% of 1990 papers
Abstract
Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), oxygen utilization (CMRO2) and blood volume (CBV) were measured in a group of 34 healthy volunteers (age range 22-82 yrs) using the 15O steady-state inhalation method and positron emission tomography. Between subjects CBF correlated positively with CMRO2, although the interindividual variability of the measured values was large. OER was not dependent on CMRO2, but highly negatively correlated with CBF. CBV correlated positively with CBF. When considering the values of all the regions of interest within a single subject, a strict coupling between CMRO2 and CBF, and between CBF and CBV was found, while OER was constant and independent of CBF and CMRO2. In 'pure' grey and white matter regions CMRO2, CBF and CBV decreased with age approximately 0.50% per year. In other regions the decline was less evident, most likely due to partial volume effects. OER did not change or showed a slight increase with age (maximum in the grey matter region 0.35%/yr). The results suggest diminished neuronal firing or decreased dendritic synaptic density with age.
Related Papers
- → Distinct gene expression in demyelinated white and grey matter areas of patients with multiple sclerosis(2022)18 cited
- → Mechanical properties of spinal cord grey matter and white matter in confined compression(2020)15 cited
- → Spinal cord blood flow after acute experimental cord injury in dogs(1976)118 cited
- → Expression profiles of RNA‐Seq‐based grey matter‐specific genes versus white matter‐specific genes in grey matter lesions of multiple sclerosis(2015)4 cited
- → Hexosamine in normal and pathological nerve tissue(1969)