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Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

Brain Communications2021Vol. 3(4), pp. fcab254–fcab254

Citations Over TimeTop 12% of 2021 papers

Sook‐Lei Liew, Artemis Zavaliangos‐Petropulu, Nicolas Schweighofer, Neda Jahanshad, Catherine E. Lang, Keith R. Lohse, Nerisa Banaj, Giuseppe Barisano, Lee A. Baugh, A. K. Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Charalambos C. Charalambous, Valentina Ciullo, Adriana Bastos Conforto, R. Cameron Craddock, Adrienne N. Dula, Natalia Egorova, Wuwei Feng, Kelene A. Fercho, Chris M. Gregory, Colleen A. Hanlon, Kathryn S. Hayward, Jess A. Holguin, Brenton Hordacre, Darryl Hwang, Steven A. Kautz, Mohamed Salah Khlif, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Bethany Lo, Jingchun Liu, David J. Lin, Martín Lotze, Bradley J. MacIntosh, John L. Margetis, Feroze B. Mohamed, Jan Egil Nordvik, Matthew A. Petoe, Fabrizio Piras, Sharmila Raju, Ander Ramos-Murguialday, Kate Revill, Pamela Roberts, Andrew D. Robertson, Heidi M. Schambra, Na Jin Seo, Mark S. Shiroishi, Surjo R. Soekadar, Gianfranco Spalletta, Cathy M. Stinear, Anisha Suri, Wai Kwong Tang, Gregory Thielman, Vincent Thijs, Daniela Vecchio, Nick Ward, Lars T. Westlye, Carolee J. Winstein, George F. Wittenberg, Kristin A. Wong, Chunshui Yu, Steven L. Wolf, Steven C. Cramer, Paul M. Thompson, ENIGMA Stroke Recovery Working Group, Nerisa Banaj, Giuseppe Barisano, Lee A. Baugh, Adrià Bermudo Gallaguet, Anup Bhattacharya, Bavrina Bigjahan, Michael R. Borich, Lara A. Boyd, Amy Brodtmann, Truman R. Brown, Cathrin M. Buetefisch, Winston D. Byblow, Jessica M. Cassidy, Charalambos C. Charalambous, Valentina Ciullo, Alison Cloutier, James H. Cole, Adriana Bastos Conforto, R. Cameron Craddock, Steven C. Cramer, Rosalia Dacosta Aguayo, Julie A. DiCarlo, Michael A. Dimyan, Martin Domín, Miranda Donnellly, Adrienne N. Dula, Matthew A. Edwardson, Natalia Egorova, Elsa Ermer, Mark R. Etherton, Wuwei Feng, Kelene A. Fercho, Jennifer K. Ferris, Fatemeh Geranmayeh, Chris M. Gregory, Shahram Hadidchi, Colleen A. Hanlon, Leticia Hayes, Kathryn S. Hayward, Jess A. Holguin, Brenton Hordacre, Darryl Hwang, Neda Jahanshad, Keith Jamison, Julia M. Juliano, Steven A. Kautz, Mohamed Salah Khlif, Bokkyu Kim, Hosung Kim, Amy Kuceyeski, Catherine E. Lang, Jenny Lee, Sook‐Lei Liew, David Lin, Jingchun Liu, Bethany Lo, Keith R. Lohse, Martin Lotze, Bradley J. MacIntosh, John L. Margetis, Daniel S. Margulies, María Mataró, Keith McGregor, Feroze B. Mohamed, Jan Egil Nordvik, Emily Olafson, Alexandre Perera-Lluna, Matthew A. Petoe, Aaron A. Phillips, Fabrizio Piras, Sharmila Raju, Ander Ramos-Murguialday, Kate Revill, Pamela Roberts, Andrew D. Robertson, Jane Maryam Rondina, Natalia S. Rost, Nerses Sanossian, Heidi M. Schambra, Christian Schranz, Nicolas Schweighofer, Na Jin Seo, Farshid Sepehrband, Mark S. Shiroishi, Julia Pia Simon, Surjo R. Soekadar, Gianfranco Spalletta, Shraddha Srivastava, Jill Campbell Stewart, Cathy M. Stinear, Anisha Suri, Myriam Taga, Wai Kwong Tang, Gregory Thielman, Vincent Thijs, Sophia I. Thomopoulos, Paul M. Thompson, Daniela Vecchio, Steven Warach, Nick Ward, Emilio Werden, Lars T. Westlye, Roland Wiest, Carolee J. Winstein, George F. Wittenberg, Steven L. Wolf, Kristin A. Wong, Chunshui Yu, Artemis Zavaliangos‐Petropulu

Abstract

Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T₁-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P n = 179; d = 0.68) and subacute (n = 274, d = 0.46) stroke. In chronic stroke (n = 404), worse sensorimotor behaviour was associated with smaller ipsilesional putamen (d = 0.52) and nucleus accumbens (d = 0.39) volumes, and a larger ipsilesional lateral ventricle (d = -0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n = 256) was associated with smaller ipsilesional putamen (d = 0.72) and larger lateral ventricle (d = -0.41) volumes, while several measures of activity limitations (n = 116) showed no significant relationships. In the full cohort across all time (n = 828), sensorimotor behaviour was associated with the volumes of the ipsilesional nucleus accumbens (d = 0.23), putamen (d = 0.33), thalamus (d = 0.33) and lateral ventricle (d = -0.23). We demonstrate significant relationships between post-stroke sensorimotor behaviour and reduced volumes of deep grey matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings provide additional insight into how different cortico-thalamo-striatal circuits support post-stroke sensorimotor outcomes.

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