Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity
Clinical Infectious Diseases2020Vol. 73(9), pp. e2932–e2942
Citations Over TimeTop 10% of 2020 papers
Barnaby Edward Young, Sean Wei Xiang Ong, Lisa F. P. Ng, Danielle E. Anderson, Wan Ni Chia, Po Ying Chia, Li Wei Ang, Tze Minn Mak, Shirin Kalimuddin, Louis Yi Ann Chai, Surinder Pada, Seow Yen Tan, Louisa Sun, Purnima Parthasarathy, Siew‐Wai Fong, Yi‐Hao Chan, Chee Wah Tan, Bernett Lee, Olaf Rötzschke, Ying Ding, Paul Anantharajah Tambyah, Jenny G. Low, Lin Cui, Timothy Barkham, Raymond Tzer Pin Lin, Yee‐Sin Leo, Laurent Rénia, Lin‐Fa Wang, David Chien Lye, Poh Lian Lim, Brenda Ang, Cheng Chuan Lee, Lawrence S. Lee, Li Min Ling, Oon Tek Ng, Mónica Chan, Kalisvar Marimuthu, Shawn Vasoo, Chen Seong Wong, Tau Hong Lee, Sapna P. Sadarangani, Ray Junhao Lin, Mucheli Sharavan Sadasiv, Deborah Hee Ling Ng, Chiaw Yee Choy, Glorijoy Shi En Tan, Yu Kit Tan, Stephanie Sutjipto, Pei Hua Lee, Jun Yang Tay, Tsin Wen Yeo, Bo Yan Khoo, Woo Chiao Tay, Gabrielle Ng, Yun Yuan Mah, Wilnard Tan, Partha Pratim De, Rao Pooja, Jonathan W. Z. Chia, Yuan Yi Constance Chen, Shehara M Mendis, Boon Kiat Toh, Raymond Fong, Helen May Lin Oh, Jaime Mei Fong Chien, Humaira Shafi, Hau Yiang Cheong, Thean Yen Tan, Thuan Tong Tan, Ban Hock Tan, Limin Wijaya, Indumathi Venkatachalam, Ying Ying Chua, Benjamin Pei Zhi Cherng, Yvonne Fu Zi Chan, Hei Man Wong, Siew Yee Thien, Kenneth Choon Meng Goh, Shireen Yan Ling Tan, Lynette Lin Ean Oon, Kian Sing Chan, Li Lin, Douglas Chan, Say Tat Ooi, Deepak Rama Narayana, Jyoti Somani, Jolene Oon, Gabriel Yan, David Michael Allen, Roland Jureen, Benedict Yan, Randy Foo, Adrian Kang Eng Zheng, Velraj Sivalingam, Wilson How, Norman Leo Fernandez, Nicholas Kim‐Wah Yeo, Rhonda Sin‐Ling Chee, Siti Naqiah Amrun
Abstract
We found virus viability was associated with lower PCR Ct value in early illness. A stronger antibody response was associated with disease severity. The overactive proinflammatory immune signatures offer targets for host-directed immunotherapy, which should be evaluated in randomized controlled trials.
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