Innate, T-, and B-Cell Responses in Acute Human Zika Patients
Clinical Infectious Diseases2017Vol. 66(1), pp. 1–10
Citations Over TimeTop 10% of 2017 papers
Lilin Lai, Nadine Rouphael, Yongxian Xu, Muktha S. Natrajan, Allison Beck, M H Hart, Matthew Feldhammer, Amanda Feldpausch, Charles E. Hill, Henry M. Wu, Jessica K. Fairley, Pamela Lankford-Turner, Nicole Kasher, Patrick Rago, Yi‐Juan Hu, Srilatha Edupuganti, Shital M. Patel, Kristy O. Murray, Mark J. Mulligan, Emory Zika Patient Study Team, Briyana Domjahn, Dongli Wang, Mary Bower, Rijalda Deović, Sree Latha Aramgam, Sara Johnson, Dean J. Kleinhenz, Joann Sadowski, Talib Sirajud-Deen, Jesse J. Waggoner
Abstract
Acute infections with Zika virus modulated antigen-presenting cell populations early. Flavivirus-experienced patients quickly recalled cross-reactive MBCs to secrete antibodies. Dengue virus-naive patients made little dengue-specific antibody but developed MBCs that cross-reacted against dengue virus. Zika virus-specific functional CD4+ T cells were readily detected, but few CD8+ T cells specific for the tested peptides were found.
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