A newKCNQ1mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome
Cardiovascular Research2015Vol. 107(4), pp. 613–623
Citations Over TimeTop 10% of 2015 papers
Cristina Moreno, Anna Oliveras, Alicia de la Cruz, Chiara Bartolucci, Carmen Muñoz‐Esparza, Eladia Salar, Juan R. Gimeno, Stefano Severi, Núria Comes, Antônio Felipe, Teresa González, Pier D. Lambiase, Carmen Valenzuela
Abstract
The F279I mutation induces a gain of function of IKs due to an impaired gating modulation of Kv7.1 induced by KCNE1, leading to a shortening of the cardiac AP.
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