Mendelian randomization of blood lipids for coronary heart disease
European Heart Journal2014Vol. 36(9), pp. 539–550
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Michael V. Holmes, Folkert W. Asselbergs, Tom Palmer, Fotios Drenos, Matthew B. Lanktree, Christopher P. Nelson, Caroline Dale, Sandosh Padmanabhan, Chris Finan, Daniel I. Swerdlow, Vinicius Tragante, Erik P.A. van Iperen, Suthesh Sivapalaratnam, Sonia Shah, Clara C. Elbers, Tina Shah, Jorgen Engmann, Claudia Giambartolomei, Jon White, Delilah Zabaneh, Reecha Sofat, Stela McLachlan, Pieter A. Doevendans, Anthony J. Balmforth, Alistair S. Hall, Kari E. North, Berta Almoguera, Ron C. Hoogeveen, Mary Cushman, Myriam Fornage, Sanjay R. Patel, Susan Redline, David S. Siscovick, Michael Y. Tsai, Konrad J. Karczewski, Marten H. Hofker, W. M. Monique Verschuren, Michiel L. Bots, Yvonne T. van der Schouw, Olle Melander, Anna F. Dominiczak, Richard Morris, Yoav Ben‐Shlomo, Jackie F. Price, Meena Kumari, Jens Baumert, Annette Peters, Barbara Thorand, Wolfgang Köenig, Tom R. Gaunt, Steve E. Humphries, Robert Clarke, Hugh Watkins, Martin Farrall, James G. Wilson, Stephen S. Rich, Paul I. W. de Bakker, Leslie A. Lange, George Davey Smith, Alex P. Reiner, Philippa J. Talmud, Mika Kivimäki, Debbie A. Lawlor, Frank Dudbridge, Nilesh J. Samani, Brendan J. Keating, Aroon D. Hingorani, Juan P. Casas
Abstract
The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain.
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