The cardiac sympathetic co-transmitter neuropeptide Y is pro-arrhythmic following ST-elevation myocardial infarction despite beta-blockade
European Heart Journal2019Vol. 41(23), pp. 2168–2179
Citations Over TimeTop 10% of 2019 papers
Manish Kalla, Guoliang Hao, Nidi Tapoulal, Jakub Tomek, Kun Liu, Lavinia Woodward, ‘Oxford Acute Myocardial Infarction (OxAMI) Study’, Erica Dall’Armellina, Adrian Banning, Robin P. Choudhury, Stefan Neubauer, Rajesh Kharbanda, Keith M. Channon, Olujimi A. Ajijola, Kalyanam Shivkumar, David J. Paterson, Neil Herring
Abstract
The co-transmitter NPY is released during sympathetic stimulation and acts as a novel arrhythmic trigger. Drugs inhibiting the Y1 receptor work synergistically with beta-blockade as a new anti-arrhythmic therapy.
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