Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD
Inflammatory Bowel Diseases2020Vol. 26(6), pp. 797–808
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Juan F. Burgueño, Adrian Reich, Hajar Hazime, Maria A. Quintero, Irina Fernández, Júlia Fritsch, Ana M. Santander, Nivis Brito, Oriana M. Damas, Amar R. Deshpande, David H. Kerman, Lanyu Zhang, Zhen Gao, Yuguang Ban, Lily Wang, Judith Pignac-Kobinger, María T. Abreu
Abstract
The viral entry molecules ACE2 and TMPRSS2 are expressed in the ileum and colon. Patients with IBD do not have higher expression during inflammation; medical therapy is associated with lower levels of ACE2. These data provide reassurance for patients with IBD.
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