Hypothalamic-Pituitary-Adrenal Axis Dysfunction and Illness Progression in Bipolar Disorder
The International Journal of Neuropsychopharmacology2014Vol. 18(1), pp. pyu043–pyu043
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Gabriel R. Fries, Mirela Paiva Vasconcelos-Moreno, Carolina Gubert, B. T. M. Q. d. Santos, J. Sartori, Barbara Schneider Eisele, Paolo Ferrari, Adam Fijtman, Joëlle Rüegg, Nils C. Gassen, Flávio Kapczinski, Theo Rein, Márcia Kauer-Sant’Anna
Abstract
Our data suggest that the epigenetic modulation of the FKBP5 gene, along with increased FKBP51 levels, is associated with the GR hyporesponsiveness seen in BD patients. Our findings are consistent with the notion that unaffected first-degree relatives of BD patients share biological factors that influence the disorder, and that such changes are more pronounced in the late stages of the illness.
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