FKBP5 Genotype-Dependent DNA Methylation and mRNA Regulation After Psychosocial Stress in Remitted Depression and Healthy Controls
The International Journal of Neuropsychopharmacology2014Vol. 18(4), pp. pyu087–pyu087
Citations Over TimeTop 10% of 2014 papers
Nina Höhne, Michael Poidinger, Frieder Merz, Hildegard Pfister, Tanja Brückl, Petra Zimmermann, M Uhr, F. Holsboer, Marcus Ising
Abstract
The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after psychosocial stress in healthy controls but not in remitted depression. Preliminary results of the DNA methylation analysis suggest that epigenetic modifications could be involved.
Related Papers
- → The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders(2009)949 cited
- → Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls(2008)315 cited
- → Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5(2021)104 cited
- → Changes of DNA methylation of Isoetes sinensis under Pb and Cd stress(2018)15 cited
- → Effect of psychosocial stress on FKBP5 and NR3C1 gene expression in healthy young men(2012)1 cited