Evidence-Based Study Design for Hospital-Acquired Bacterial Pneumonia and Ventilator-Associated Bacterial Pneumonia
The Journal of Infectious Diseases2018Vol. 219(10), pp. 1536–1544
Citations Over TimeTop 10% of 2018 papers
George H. Talbot, Anita Das, Stephanie S. Cush, Aaron Dane, Michele Wible, Roger Echols, Antoní Torres, Sue Cammarata, John Rex, John H. Powers, Thomas Fleming, Jeffrey S Loutit, Steve Hoffmann
Abstract
If disease groups and patient characteristics in future studies produce an ACM rate so low (<10%-15%) that a fixed noninferiority margin of 10% cannot be justified (requiring an odds ratio analysis), an ACM+ endpoint could lower sample size. Enrichment of studies with patients with a higher severity of illness would increase ACM. Data on symptom resolution in nonventilated HABP support development of a patient-reported outcome instrument.
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