Extensive drug resistance during low-level HIV viraemia while taking NNRTI-based ART supports lowering the viral load threshold for regimen switch in resource-limited settings: a pre-planned analysis from the SESOTHO trial
Journal of Antimicrobial Chemotherapy2021Vol. 76(5), pp. 1294–1298
Citations Over TimeTop 23% of 2021 papers
Jennifer Anne Brown, Alain Amstutz, Bienvenu Lengo Nsakala, Ulrike Seeburg, Fiona Vanobberghen, Josephine Muhairwe, Thomas Klimkait, Niklaus Daniel Labhardt
Abstract
Among persons with low-level viraemia while taking NNRTI-based first-line ART enrolled in the SESOTHO trial, the majority harboured HIV-1 with RAMs that necessitate ART modification. These findings support lowering the VL threshold triggering a switch to second-line ART in future WHO guidelines.
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