Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study
Journal of Antimicrobial Chemotherapy2021Vol. 76(9), pp. 2342–2351
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Valentin al Jalali, Michael Wölfl‐Duchek, Max Taubert, Peter Matzneller, Edith Lackner, Christoph Dorn, Alexander Kratzer, Beatrix Wulkersdorfer, Zoe Österreicher, Markus Zeitlinger
Abstract
Tazobactam %T>CT values were distinctly below proposed target values, indicating that tazobactam might be underdosed in the investigated drug combination. However, ISF/unbound plasma ratios of ceftolozane and tazobactam support their use in soft tissue infections. A plasma and soft tissue PK model adds important information on the PK profile of ceftolozane/tazobactam. Further investigations in patients suffering from wound infections are needed to confirm these findings.
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