Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania
Journal of Antimicrobial Chemotherapy2021Vol. 77(2), pp. 483–491
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Shimba Henerico, Sello Given Mikasi, Samuel Kalluvya, Jan Brauner, Seif Abdul, Eric Lyimo, Bernard Desderius, Klaus Korn, Gert U. van Zyl, Graeme Brendon Jacobs, Wolfgang Preiser, Christa Kasang
Abstract
The Tanzanian national guidelines define 'virological failure' as two consecutive viral load measurement results, at 3 month intervals, above the WHO threshold (1000 copies/mL). Here, we show that a single viral load above the WHO threshold is associated with high rates of RAMs. This suggests that a single high viral load measurement could be used to predict virological failure and avoid delays in switching patients from first-line to higher genetic barrier second-line regimens.
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