Effects of prolonged vancomycin administration on methicillin-resistant Staphylococcus aureus (MRSA) in a patient with recurrent bacteraemia
Journal of Antimicrobial Chemotherapy2006Vol. 57(4), pp. 699–704
Citations Over TimeTop 10% of 2006 papers
George Sakoulas, Howard S. Gold, Robert A. Cohen, Lata Venkataraman, Robert C. Moellering, George M. Eliopoulos
Abstract
Despite the lack of development of detectable resistance, MRSA exposed to vancomycin for prolonged periods may begin to develop vancomycin tolerance and decreased autolysis. In addition, suppression of agr function appears to end after vancomycin is stopped. Whether these changes are prerequisites for attenuated vancomycin efficacy and the development of glycopeptide resistance warrants further study. The development of vancomycin resistance may be more difficult under conditions where vancomycin serum concentrations are maintained >10 mg/L.
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