Increased mutability of Pseudomonas aeruginosa in biofilms
Journal of Antimicrobial Chemotherapy2008Vol. 61(5), pp. 1053–1056
Citations Over TimeTop 10% of 2008 papers
Abstract
Down-regulation of antioxidant enzymes in P. aeruginosa biofilms may enhance the rate of mutagenic events due to the accumulation of DNA damage. Since P. aeruginosa forms biofilms in the CF lung, this mode of growth may enhance the direct selection of antibiotic-resistant organisms in CF patients and also increase the opportunity to derive permanent hypermutators thereby providing a further source of antibiotic-resistant mutants in the CF lung.
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