Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential
Journal of Antimicrobial Chemotherapy2013Vol. 69(4), pp. 1005–1016
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Thomas Antoine, Nicholas Fisher, Richard K. Amewu, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Abstract
The depolarization of ΔΨm and ΔΨp is shown to be mediated via the generation of ROS that are initiated by iron bioactivation of endoperoxides and/or catalysed by iron-dependent oxidative stress. These data are discussed in the context of current hypotheses concerning the mode of action of endoperoxides.
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