β-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium
Journal of Antimicrobial Chemotherapy2015Vol. 70(6), pp. 1738–1743
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Jordan R. Smith, Katie E. Barber, Animesh Raut, Mostafa Aboutaleb, George Sakoulas, Michael J. Rybak
Abstract
The data support the potential use of daptomycin/BL combination therapy in infections caused by VRE. Combination regimens, other than those involving cefazolin and cefotaxime, provide better kill compared with daptomycin alone. Further clinical research involving daptomycin combinations is warranted.
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