Penetrance of Breast Cancer Susceptibility Genes From the eMERGE III Network
JNCI Cancer Spectrum2021Vol. 5(4)
Citations Over TimeTop 10% of 2021 papers
Xiao Fan, Julia Wynn, Ning Shang, Cong Liu, Alexander Fedotov, Miranda L. G. Hallquist, Adam H. Buchanan, Marc S. Williams, Maureen E. Smith, Christin Hoell, Laura J. Rasmussen‐Torvik, Josh F. Peterson, Georgia L. Wiesner, Andrea M. Murad, Gail P. Jarvik, Allan Gordon, Elisabeth A. Rosenthal, Ian B. Stanaway, David R. Crosslin, Eric B. Larson, Kathleen A. Leppig, Nora B. Henrikson, Janet L. Williams, Rongling Li, Scott J. Hebbring, Chunhua Weng, Yufeng Shen, Katherine D. Crew, Wendy K. Chung
Abstract
Our study provides population-based penetrance estimates for the understudied genes CHEK2, ATM, and PALB2 and highlights the importance of using unselected populations for penetrance studies. It also demonstrates the potential clinical impact of genetic testing to improve health care through early diagnosis and preventative screening.
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